Editorial Overview: Controversies in Anticoagulant Therapy

Overview of direct oral anticoagulant therapy reversal.

PURPOSE Strategies for the management of bleeding complications and facilitation of an invasive procedure in patients receiving direct oral anticoagulants (DOACs) are reviewed. SUMMARY The DOACs provide clinical advantages versus vitamin K antagonists, including fixed dosing with no routine coagulation monitoring and evidence of a lower risk of bleeding. However, as with all anticoagulants, t...

Current Controversies in Lupus Anticoagulant Detection

Antiphospholipid syndrome is an autoimmune, acquired thrombophilia diagnosed when vascular thrombosis or pregnancy morbidity are accompanied by persistent antiphospholipid antibodies. Lupus anticoagulants (LA) are one of the criteria antibodies but calibration plasmas are unavailable and they are detected by inference based on antibody behaviour in a medley of coagulation-based assays. Elevated...

Editorial overview.

Editorial overview

Computational analysis tools and decision support systems have increased their penetration in the support of clinical processes and management of medical data and knowledge. Applications range from adjunct tools for diagnosis and disease investigation to the treatment and monitoring of therapeutic procedures. As all medical fields, the field of oncology is affected. This special issue includes ...

Overview of the epidemiologic research: Editorial Guidelines

Epidemiology can be considered as a very old science. For example, John Graunt, a statistician, published Natural and Political Observations. In the Bills of Mortality in 1662, he analyzed the mortality rolls in London before the Great Plague, presented one of the first life tables, and reported time trends for many diseases. He provided statist...